Identify Changes of Brain Regional Homogeneity in Bipolar Disorder and Unipolar Depression Using Resting-State fMRI |
| |
Authors: | Min-Jie Liang Quan Zhou Kan-Rong Yang Xiao-Ling Yang Jin Fang Wen-Li Chen Zheng Huang |
| |
Institution: | 1. Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.; 2. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou, Guangdong, China.; 3. Department of Electronic Engineering and CAPT Laboratory, University of Colorado Denver, Aurora, Colorado, United States of America.; Banner Alzheimer''s Institute, United States of America, |
| |
Abstract: | BackgroundTo identify changes in brain activation patterns in bipolar disorder (BD) and unipolar depression (UD) patients.Methodology/Principal FindingsResting-state fMRI scans of 16 healthy controls, 17 BD and 16 UD patients were obtained. T-test of normalized regional homogeneity (ReHo) was performed in a voxel-by-voxel manner. A combined threshold of á = 0.05, minimum cluster volume of V = 10503 mm3 (389 voxels) were used to determine ReHo differences between groups. In UD group, fMRI revealed ReHo increases in the left middle occipital lobe, right inferior parietal lobule, right precuneus and left convolution; and ReHo decreases in the left parahippocampalgyrus, right precentralgyrus, left postcentralgyrus, left precentralgyrus and left cingulated. In BD group, ReHo increases in the right insular cortex, left middle frontal gyrus, left precuneus, left occipital lobe, left parietal, left superior frontal gyrus and left thalamus; and ReHo decreases in the right anterior lobe of cerebellum, pons, right precentralgyrus, left postcentralgyrus, left inferior frontal gyrus, and right cingulate. There were some overlaps in ReHo profiles between UD and BD groups, but a marked difference was seen in the thalamus of BD.Conclusions/SignificanceThe resting-state fMRI and ReHo mapping are a promising tool to assist the detection of functional deficits and distinguish clinical and pathophysiological signs of BD and UD. |
| |
Keywords: | |
|
|