Antitumor promoting activities of 3-O-acyl-(-)epigallocatechins |
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| Authors: | Uesato S Kitagawa Y Hara Y Tokuda H Okuda M Mou X Y Mukainaka T Nishino H |
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| Affiliation: | Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp |
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| Abstract: | As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects. |
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