Brush border enzymes as markers for ascending pyelonephritis: active immunization with pili |
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| Authors: | U.C. Garg N.K. Ganguly S. Sharma R. Bhatnagar |
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| Affiliation: | Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;Panjab University, Chandigarh, India;Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, MD, U.S.A. |
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| Abstract: | Activities of renal brush border membrane (BBM) enzymes, alkaline phosphatase, maltase and leucine aminopeptidase, were determined in control, pyelonephritic and immunized-infected rats. The activities of all enzymes decreased significantly (P < 0.05) in obstructed kidney while activities of alkaline phosphatase and leucine aminopeptidase increased significantly (P < 0.05) in unobstructed kidney in early stages of infection. The affinity constant (Km) of all enzymes remained unaltered in control and experimental groups. Significant differences (P < 0.05) in the activities of BBM enzymes of infected and immunized-infected animals suggested a protective role of active immunization with pili. |
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| Keywords: | Ascending pyelonephritis Pili Brush border membrane enzyme Active immunization |
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