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Fibroblast biology: Development and differentiation of synovial fibroblasts in arthritis
Authors:CW Jonathan Edwards
Affiliation:(1) UCL Centre for Rheumatology, London, UK
Abstract:Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.
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