Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli |
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| Authors: | Gomez-Duarte Oscar G Chattopadhyay Sujay Weissman Scott J Giron Jorge A Kaper James B Sokurenko Evgeni V |
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| Institution: | Division of Pediatric Infectious Diseases, University of Iowa Children's Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA. oscar-gomez@uiowa.edu |
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| Abstract: | Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer. |
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