首页 | 本学科首页   官方微博 | 高级检索  
     


Comparison of bone marrow extracellular matrices.
Authors:M Lee  I P Christopherson  J M Lehman  C J Bennett  H T Cheung
Affiliation:Department of Biological Sciences, Illinois State University, Normal, IL, 61790-4120, USA. mlee@molbio.princeton.edu
Abstract:We have compared the structure and composition of adult and fetal bovine bone marrow extracellular matrices. In contrast to fetal bone marrow, adult bone marrow has more oval fenestration and accumulation of adipocytes as well as lower protein content. These differences could be due to remodeling of bone marrow tissue as it develops. Zymogram analysis of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) activities showed that fetal, but not adult bone marrow extract contained a 96-kDa MMP and TIMP-1 and -2. These activities may contribute to the structural differences between adult and fetal bone marrow tissues.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号