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Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms
Affiliation:1. Chair of Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany;2. Nutritional Medicine Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München, 85350 Freising-Weihenstephan, Germany;3. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany;4. Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany and Technische Universität München, 85350 Freising-Weihenstephan, Germany;5. Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA 02131, USA;6. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway;7. K.G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5021 Bergen, Norway;8. Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway;9. Genomatix Software GmbH, 80335 Munich, Germany;10. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany;11. Institut für Humangenetik, Universitätsklinikum Essen, Universität-Duisburg-Essen, 45147 Essen, Germany;12. Diabetes and Endocrinology Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden;13. Chair of Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany;14. Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 89081 Ulm, Germany;15. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany;16. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany;17. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, 81377 Munich, Germany;18. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany;19. Research Unit Stem Cell Dynamics, Helmholtz Center Munich-German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany;20. Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, 4058 Basel, Switzerland;21. Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, German Research Center for Environmental Health, Germany;22. Department of Neurology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;23. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA;24. Department of Medicine, Karolinska Institutet, Center for Endocrinology and Metabolism, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden;25. Research Unit Protein Science, Helmholtz Zentrum München, 85764 Neuherberg, Germany;26. Department of Medicine, University of Leipzig, 04103 Leipzig, Germany;27. Hanover Unified Biobank, Hanover Medical School, 30625 Hanover, Germany;28. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany;29. Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar;30. Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA 02115, USA;31. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;32. Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany;1. Chair of Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany;2. Nutritional Medicine Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München, 85350 Freising-Weihenstephan, Germany;3. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany;4. Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany and Technische Universität München, 85350 Freising-Weihenstephan, Germany;5. Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA 02131, USA;6. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway;7. K.G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5021 Bergen, Norway;8. Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway;9. Genomatix Software GmbH, 80335 Munich, Germany;10. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany;11. Institut für Humangenetik, Universitätsklinikum Essen, Universität-Duisburg-Essen, 45147 Essen, Germany;12. Diabetes and Endocrinology Research Unit, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden;13. Chair of Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius-Center for Nutritional Medicine, 85350 Freising-Weihenstephan, Germany;14. Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 89081 Ulm, Germany;15. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany;16. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany;17. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, 81377 Munich, Germany;18. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany;19. Research Unit Stem Cell Dynamics, Helmholtz Center Munich-German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany;20. Department of Biosystems Science and Engineering (D-BSSE), ETH Zurich, 4058 Basel, Switzerland;21. Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, German Research Center for Environmental Health, Germany;22. Department of Neurology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;23. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA;24. Department of Medicine, Karolinska Institutet, Center for Endocrinology and Metabolism, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden;25. Research Unit Protein Science, Helmholtz Zentrum München, 85764 Neuherberg, Germany;26. Department of Medicine, University of Leipzig, 04103 Leipzig, Germany;27. Hanover Unified Biobank, Hanover Medical School, 30625 Hanover, Germany;28. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany;29. Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar;30. Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA 02115, USA;31. Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;32. Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany
Abstract:
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