Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study

Authors:	Caroline Jézéquel Fabrice Lainé Bruno Laviolle Anita Kiani Edouard Bardou-Jacquet Yves Deugnier

Affiliation:	1. CHU Rennes, Liver Unit, F-35033, Rennes, France.; 2. INSERM, CIC 1414, F-35033, Rennes, France.; 3. University Rennes 1, Faculty of Medicine, F- 35043, Rennes, France.; 4. CHU Rennes, Department of Radiology, F-35033, Rennes, France.; 5. INSERM, U991, F-35033, Rennes, France.; Lady Davis Institute for Medical Research/McGill University, CANADA,

Abstract:	Background & Aims Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). Methods We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. Results The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.

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