Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres |
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Authors: | Sally F. Gilliver David A. Jones Jörn Rittweger Hans Degens |
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Affiliation: | 1.Institute for Biomedical Research into Human Movement and Health,Manchester Metropolitan University,Manchester,UK;2.Department for Space Physiology, Institute of Aerospace Medicine,German Aerospace Center (DLR),Cologne,Germany |
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Abstract: | We explored to which extent maximal velocity of shortening (Vmax), force per cross-sectional area (specific tension, Po) and curvature of the force–velocity relationship (a/Po in the Hill equation) contribute to differences in peak power of single, chemically skinned rat type I fibres. Force–velocity relationships were determined from isotonic contractions of 94 maximally activated fibres. Peak power (±SD) was 3.50 ± 1.64 W L−1. There was a tenfold range of peak power and five-, six- and fourfold ranges for Po, Vmax and a/Po, respectively. None of the differences between fibres was explicable by differences in myosin heavy or light chain composition. The inverse relationship between a/Po and Vmax suggests a similar underlying cause. Fitting the data to the Huxley (Progr Biophys Biophys Chem 7:255–318, 1957) cross-bridge model showed that the rate constant g 2 and the sum of the rate constants (f + g 1) co-varied, both being low in the slowest fibres. Approximately 16% of the variation in Po could be explained by variation in the proportion of attached cycling cross-bridges (f/(f + g 1)), but the origin of most of the variance in Po remains unknown. |
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