The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis |
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| Authors: | Haomeng Zhang Jiao Wang Yulong Yin Qingjie Meng Yonggang Lyu |
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| Institution: | 1.Department of Thyroid and Breast Surgery, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, Fengcheng 3rd Road 10, Weiyang District, Xi’an, Shaanxi 710018, P. R. China;2.Department of Radiotherapy, The First Affiliated Hospital of Xi''an Jiaotong University, Yanta West Road 277, Yanta District, Xi’an, Shaanxi 710061, P. R. China |
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| Abstract: | Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial–mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC. |
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| Keywords: | Triple-negative breast cancer(TNBC) long non-coding RNA(LncRNA) Metastasis Epithelial-mesenchymal transition(EMT) |
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