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CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway |
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| Authors: | Yann Deleye Alexia Karen Cotte Sarah Anissa Hannou Nathalie Hennuyer Lucie Bernard Bruno Derudas Sandrine Caron Vanessa Legry Emmanuelle Vallez Emilie Dorchies Nathalie Martin Steve Lancel Jean Sbastien Annicotte Kadiombo Bantubungi Albin Pourtier Violeta Raverdy Franois Pattou Philippe Lefebvre Corinne Abbadie Bart Staels Joel T Haas Rjane Paumelle |
| Institution: | 1.Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France;2.Univ. Lille, CNRSInstitut Pasteur de Lille, UMR 8161–M3T–Mechanisms of Tumorigenesis and Target Therapies, Lille, France;3.Univ. Lille, CNRSCHU Lille, Institut Pasteur de Lille, UMR 8199–EGID, Lille, France;4.Univ. Lille, Inserm, CHU Lille, UMR 1190–EGID, Lille, France |
| Abstract: | |
| Keywords: | CDKN2A PPARα liver lipid metabolism fatty acid oxidation AMPKα steatosis cell cycle peroxisome proliferator-activated receptor (PPAR) AMP-activated kinase (AMPK) |