Solanesyl diphosphate synthase reaction with artificial substrates. Formation of R and S-enantiomers of 4- and 8- methyl derivatives of geranylgeranyl diphosphate |
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Authors: | Shin-ichi Ohnuma Tanetoshi Koyama Kyozo Ogura |
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Institution: | Institute for Chemical Reaction Science, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai, Miyagi 980 Japan |
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Abstract: | (E)- and (Z-3-Methyl-3-pentenyl diphosphates acted as artificial substrates in the reaction with geranyl diphosphate catalyzed by solanesyl diphosphate synthase of Micrococcus luteus. The reactions of the E- and Z-isomers proceeded in the same stereochemical manner as that with the natural substrate but stopped at the stage of two steps of condensation, forming C16- and C22-prenyl diphosphates having extra one and two methyl groups at 4- and 4,8-positions, respectively. |
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