Effect of rifampicin on development of tolerance to analgesic actions. |
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| Authors: | W H Gispen W A Krivoy D de Wied E Zimmermann |
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| Affiliation: | 1. Division of Molecular Neurobiology, Institute of Molecular Biology, Padualaan 8, Utrecht, The Netherlands;2. National Institute on Drug Abuse, Addiction Research Center, Lexington, Ky., U.S.A.;3. Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Utrecht, The Netherlands;4. Department of Anatomy and Brain Research Institute, University of California, School of Medicine, Los Angeles, California, U.S.A. |
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| Abstract: | Two series of experiments were performed. In the first series the reaction times of mice were determined using the hotplate technique. In the second series of experiments the reactions of rats were determined using the electric footshock technique. In both series of experiments morphine was observed to alter the responses, and chronic morphine administration resulted in tolerance to these actions of morphine. In both series of experiments, tolerance, defined by these same criteria, was inhibited by the concurrent administration of rifampicin. |
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