UPTAKE AND RELEASE OF TAURINE FROM RAT BRAIN SLICES |
| |
| Authors: | L. K. Kaczmarek A. N. Davison |
| |
| Affiliation: | Department of Neurochemistry, Institute of Neurology, Queen Square, London, WCIN 3BG |
| |
| Abstract: | Abstract— Rapid efflux of [35S]taurine from rat brain slices was observed on electrical stimulation. Slower release resulted when the Ca2+ content of the perfusion medium was replaced with Mg2+. Uptake of [35S]taurine into rat cortical slices was unaffected by GABA, glutamic acid, glycine and leucine but was inhibited by alanine, ouabain, KCN and 2,4-dinitrophenol. Of a number of analogues of taurine, 2-aminoethylsulphinic acid was the most potent in inhibiting the uptake of [35S]taurine. The rate of uptake was found to be decreased by lowering the incubation temperature. The possibility that taurine may be a neurotransmitter is discussed. |
| |
| Keywords: | |
|
|
