UPTAKE AND RELEASE OF TAURINE FROM RAT BRAIN SLICES |
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| Authors: | L K Kaczmarek A N Davison |
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| Institution: | Department of Neurochemistry, Institute of Neurology, Queen Square, London, WCIN 3BG |
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| Abstract: | Abstract— Rapid efflux of 35S]taurine from rat brain slices was observed on electrical stimulation. Slower release resulted when the Ca2+ content of the perfusion medium was replaced with Mg2+. Uptake of 35S]taurine into rat cortical slices was unaffected by GABA, glutamic acid, glycine and leucine but was inhibited by alanine, ouabain, KCN and 2,4-dinitrophenol. Of a number of analogues of taurine, 2-aminoethylsulphinic acid was the most potent in inhibiting the uptake of 35S]taurine. The rate of uptake was found to be decreased by lowering the incubation temperature. The possibility that taurine may be a neurotransmitter is discussed. |
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