Measuring principles of frictional coefficients in cartilaginous tissues and its substitutes |
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Authors: | Huyghe J M Janssen C F Van Donkelaar C C Lanir Y |
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Institution: | Department of Biomedical Engineering, Engineering Mechanics Institute, Eindhoven University of Technology, Eindhoven, The Netherlands. jacques@wfw.wtb.tue.nl |
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Abstract: | The frictional properties of cartilaginous tissues, such as the hydraulic permeability, the electro-osmotic permeability, the diffusion coefficients of various ions and solutes, and the electrical conductance, are vital data to characterise the extracellular environment in which chondrocytes reside. This paper analyses one-dimensional measurement principles of these coefficients. Particular attention is given to the deformation dependence of them and the highly deformable nature of the tissues. A suggested strategy is the combination of a diffusion experiment using radiotracer methods, an electro-osmotic flow experiment and an electro-osmotic pressure experiment at low electric current. |
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