The Differential Killing of Genes by Inversions in Prokaryotic Genomes |
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Authors: | Paweł Mackiewicz Dorota Mackiewicz Agnieszka Gierlik Maria Kowalczuk Aleksandra Nowicka Małgorzata Dudkiewicz Mirosław R Dudek Stanisław Cebrat |
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Institution: | (1) Institute of Microbiology, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wrocław, Poland, PL;(2) Institute of Physics, Zielona Góra Pedagogical University, PL |
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Abstract: | We have elaborated a method which has allowed us to estimate the direction of translocation of orthologs which have changed,
during the phylogeny, their positions on chromosome in respect to the leading or lagging role of DNA strands. We have shown
that the relative number of translocations which have switched positions of genes from the leading to the lagging DNA strand
is lower than the number of translocations which have transferred genes from the lagging strand to the leading strand of prokaryotic
genomes. This paradox could be explained by assuming that the stronger mutation pressure and selection after inversion preferentially
eliminate genes transferred from the leading to the lagging DNA strand.
Received: 12 December 2000 / Accepted: 20 April 2001 |
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Keywords: | : Gene inversion — Mutation pressure — Ortholog — DNA asymmetry — Leading — Lagging strand |
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