Synthesis of 3-C-(hydroxymethyl)erythritol and 3-C-methylerythritol |
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| Authors: | Zbigniew J Witczak Roy L Whistler James R Daniel |
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| Institution: | Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907 U.S.A.;Department of Food and Nutrition, Purdue University, West Lafayette, Indiana 47907 U.S.A. |
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| Abstract: | 3-C-(Hydroxymethyl)erythritol was prepared from 3-C-(hydroxymethyl)-2,3-O-isopropylidene-d-erythro-tetrofuranose (4) by hydrolysis followed by reduction, or by reduction followed by hydrolysis. Monotosylation of 4, followed by reduction with lithium aluminum hydride and hydrolysis, afforded 3-C-methylerythritol. |
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