2,5-anhydro-d-hexitols: syntheses of 2,5-anhydro-d-altritol and 2,5-anhydro-d-iditol |
| |
Authors: | Dario A Otero Ronald Simpson |
| |
Institution: | Sandoz, Inc., Route 10, East Hannover, NJ 07936 U.S.A. |
| |
Abstract: | 2,5-Anhydro-d-altritol (2a) and the previously-unknown 2,5-anhydro-d-iditol (3a) have been prepared from 2,5-anhydro-d-mannitol (1a). The preparation of 3a from the intermediate epoxide 7b is particularly sensitive to pH, and a mechanism is proposed to explain this. Attention is drawn to the limitations of the trifluoroperacetic acid-disodium hydrogenphosphate procedure for the epoxidation of alkenes of diminished reactivity. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|