A lumped parameter mathematical model of the splanchnic circulation. |
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Authors: | T M Chu N P Reddy |
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Affiliation: | Department of Biomedical Engineering, University of Akron, Ohio 44325. |
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Abstract: | A lumped parameter mathematical model to describe the propulsion of blood in the splanchnic circulation was developed by integrating the principles of mechanics and physiology. A set of governing equations by derived by specifically considering the contractility of the portal vein, hepatic vein, liver sinusoids, and of the draining lymphatics. These equations were then simulated on a computer. The present simulation results substantiate previous experimental observations that hepatic venous pressure leads to portal hypertension and increased liver interstitial fluid volume. |
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