Suppression subtractive hybridization identifies an autotransporter adhesin gene of <Emphasis Type="Italic">E. coli</Emphasis> IMT5155 specifically associated with avian pathogenic <Emphasis Type="Italic">Escherichia coli</Emphasis> (APEC) |
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Authors: | Jianjun Dai Shaohui Wang Doreen Guerlebeck Claudia Laturnus Sebastian Guenther Zhenyu Shi Chengping Lu Christa Ewers |
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Institution: | (1) College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China;(2) Institute of Microbiology and Epizootics, Free University Berlin, Berlin, D-10115, Germany |
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Abstract: | Background Extraintestinal pathogenic E. coli (ExPEC) represent a phylogenetically diverse group of bacteria which are implicated in a large range of infections in humans
and animals. Although subgroups of different ExPEC pathotypes, including uropathogenic, newborn meningitis causing, and avian
pathogenic E. coli (APEC) share a number of virulence features, there still might be factors specifically contributing to the pathogenesis of
a certain subset of strains or a distinct pathotype. Thus, we made use of suppression subtractive hybridization and compared
APEC strain IMT5155 (O2:K1:H5; sequence type complex 95) with human uropathogenic E. coli strain CFT073 (O6:K2:H5; sequence type complex 73) to identify factors which may complete the currently existing model of
APEC pathogenicity and further elucidate the position of this avian pathoype within the whole ExPEC group. |
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