Transformation of metabolism with age and lifestyle in Antarctic seals: a case study of systems biology approach to cross-species microarray experiment |
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| Authors: | Andrey Ptitsyn Amber Schlater Shane Kanatous |
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| Institution: | (1) Center for Bioinformatics, Colorado State University, 80523 Fort Collins, CO, USA;(2) Department of Biology, Colorado State University, 80523 Fort Collins, CO, USA |
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| Abstract: | Background The metabolic transformation that changes Weddell seal pups born on land into aquatic animals is not only interesting for
the study of general biology, but it also provides a model for the acquired and congenital muscle disorders which are associated
with oxygen metabolism in skeletal muscle. However, the analysis of gene expression in seals is hampered by the lack of specific
microarrays and the very limited annotation of known Weddell seal (Leptonychotes weddellii) genes. |
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