Alignment and clustering of phylogenetic markers - implications for microbial diversity studies |
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| Authors: | James R White Saket Navlakha Niranjan Nagarajan Mohammad-Reza Ghodsi Carl Kingsford Mihai Pop |
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| Institution: | (1) Applied Mathematics and Scientific Computation Program, University of Maryland - College Park, College Park, MD 20742, USA;(2) Department of Computer Science, University of Maryland - College Park, College Park, MD 20742, USA;(3) Center for Bioinformatics and Computational Biology, University of Maryland - College Park, College Park, MD 20742, USA;(4) Computational and Mathematical Biology Program, Genome Institute of Singapore, 138672, Singapore |
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| Abstract: | Background Molecular studies of microbial diversity have provided many insights into the bacterial communities inhabiting the human body
and the environment. A common first step in such studies is a survey of conserved marker genes (primarily 16S rRNA) to characterize
the taxonomic composition and diversity of these communities. To date, however, there exists significant variability in analysis
methods employed in these studies. |
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