Further improvement in protecting method for the oligonucleotide synthesis in terms of a cellulose acetate derivative as a polymer support. |
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| Authors: | K Kamaike T Ogawa Y Inoue Y Ishido |
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| Affiliation: | Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Tokyo College of Pharmacy, Japan. |
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| Abstract: | For further improvement in the investigation to utilize a cellulose acetate derivative as a novel type of polymer-support for the synthesis of oligonucleotides, the investigations on utilizing another spacer; on protecting groups for O6-position of guanosine unit, ribothymidine, and pseudouridine; and on a novel protecting group for the introduction of phosphate function at 5'-terminal position, targeting the syntheses of 13-mer, ApApGpGpApApApApUpUpApUpG, 11-mer, pCpUpCpGpUpCpCpApCpCpA, and 12-mer, UpCpCpGpGprTp- psipCpGpApUpU, found in the partial structures of a yeast tRNA(Ala), will be described in detail. |
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