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Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target
Authors:Kim Jung-Hwan  Lee Ki Won  Lee Min-Won  Lee Hyong Joo  Kim Sung-Hoon  Surh Young-Joon
Affiliation:College of Pharmacy, Seoul National University, Shillim-dong, Kwanak-gu, Seoul 151-742, Republic of Korea.
Abstract:
Keywords:COX-2, cyclooxygenase-2   DMEM/F12, Dulbecco’s modified Eagle’s medium/F-12 nutrient   MMP, matrix metalloproteinase   NSAID, nonsteroidal antiinflammatory agent   NF-κB, nuclear factor kappa B   PGE2, prostaglandin E2   PBS, phosphate-buffered saline   SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis   TPA, 12-O-tetradecanoylphorbol-13-acetate   TPCK, N-alpha-tosyl-  smallcaps"  >l-phenylalanine chloromethyl ketone
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