Dopamine and adult neurogenesis |
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| Authors: | Borta Andreas Höglinger Günter U |
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| Affiliation: | Experimental Neurology, Philipps University, Marburg, Germany. |
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| Abstract: | Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease? |
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| Keywords: | adult neurogenesis dopamine Parkinson's disease substantia nigra subventricular zone |
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