Using the same organocatalyst for asymmetric synthesis of both enantiomers of glutamic acid-derived Ni(II) complexes via 1,4-additions of achiral glycine and dehydroalanine Schiff base Ni(II) complexes |
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| Authors: | Yuri N. Belokon Zalina T. Gugkaeva Karine V. Hakobyan Victor I. Maleev Margarita A. Moskalenko Victor N. Khrustalev Ashot S. Saghyan Alan T. Tsaloev Kiryl K. Babievsky |
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| Affiliation: | Institute of Russian Academy of Sciences, A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov str. 28, 119991, Moscow, Russia. yubel@ineos.ac.ru |
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| Abstract: | (S)- and (R)-BIMBOL were efficient PT catalysts of asymmetric Michael addition of prochiral Ni-PBP-Gly (1) to acrylic esters and malonic esters to Ni-PBP-Δ-Ala (2) correspondingly. The salient feature of the catalysis is opposite configurations of Glu prepared via the two paths with BIMBOL of the same configuration and a perspective novel catalytic procedure for the synthesis of Gla derivatives. |
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