Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II) |
| |
Authors: | Rubino S Petruso S Pierattelli R Bruno G Stocco G C Steardo L Motta M Passerotto M Giudice E Del Gulì G |
| |
Institution: | Dipartimento di Chimica Inorganica, Università degli studi di Palermo, Viale delle Scienze, Parco d'Orleans, 90128 Palermo, Italy. |
| |
Abstract: | Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1H and 13C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of Cu(II)(2-BZP)2] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes Cu(II)(2-BZP)2] and Pt(II)(2-BZP)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 microM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 microM. While the Pt(II) complexes may have damaged DNA to induce cell death, treatment with the Cu(II) complex did not induce Jurkat cell death. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|