Effects of orally administered ethyl ester of eicosapentaenoic acid (EPA; C20:5, ω-3) on PGI2-like substance production by rat aorta |
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| Authors: | T Hamazaki A Hirai T Terano J Sajiki S Kondo T Fujita Y Tamura A Kumagai |
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| Institution: | 1. Second Department of Internal Medicine, Chiba University School of Medicine, Chiba City, 280, Japan;1. Chiba Prefectural Institute of Public Health, Chiba City, Japan;7. Research Laboratory, Nissui Seiyaku Co., Ltd., Yuki City, Japan;71. Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Hachioji City, Japan |
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| Abstract: | A highly purified ethyl ester of EPA (EPAEE) (74%) was manufactured from sardine oil. Sixty mg/kg/day of EPAEE was given orally to male Wishar rats for 8 weeks. No side effect or toxicity from the administration of EPAEE was observed. Plasma EPA concentration and the ratio of EPA to arachidonic acid were significantly increased, compared with control Wistar rats. An enhancement of PGI2-like substance production by aortas obtained from rats fed EPAEE was noted. Conversion of EPA to Λ17-6-keto-PGF1α, a stable metabolite of PGI3, could not be detected by an incubation study of 14C-EPA and aortas either from rats fed EPAEE or from control rats. Therefore, PGI2-like substance produced by rat aorta is most likely to be PGI2. itself and not PGI3. |
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