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Microviscosity of mouse splenocyte cytoplasmic membrane modified by some antibiotics
Authors:Prof Francesco Galdiero  Caterina Romano Carratelli  Concetta Bentivoglio  Immacolata Nuzzo  Marilena Galdiero
Institution:(1) Istituto di Microbiologia, I Facolta' di Medicina e Chirurgia, Larghetto s. Aniello a Caponapoli 2, 80138 Napoli, Italy
Abstract:This study has assessed the changes in the polarization fluorescence of 1,6-diphenyl-1,3,5-hexatriene in the splenic membrane of mice treated with clindamycin, penicillin, cefoxitin, cefamandole, cephaloridine, tetracycline, and erythromycin. The data show that most of the antibiotics tested modified membrane activity, as was shown by the changes in membrane microviscosity parameters.
Keywords:
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