Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines |
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| Authors: | Elban Mark A Chapuis Jean C Li Mei Hecht Sidney M |
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| Institution: | Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904, USA. |
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| Abstract: | Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described. |
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