| Abstract: | The method of superfusion of the basal membranes of the ampullae of Lorenzini of skates was used to investigate the influence of L-serine-O-phosphate (SOP) on the background and evoked activity of afferent nerve fibers, as well as on the effects of application of agonists: exciting amino acids — L-glutamate (L-GLU), kainate (KA), quisqualte (Q), and N-methyl-D-aspartate (NMDA). It was found that SOP (threshold concentration 10–7 M) had an inhibiting effect on the background and evoked activity of the nerve fibers; depending on the concentration it decreased the stimulatory effects of L-GLU and NMDA and did not change the responses due to application of KA and Q. The data obtained suggest that the effects of SOP observed in the ampullae of Lorenzini are associated with its interaction with NMDA-type amino acid receptors.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 23, No. 4, pp. 387–391, July–August, 1991. |
