Tyrosine Hydroxylase mRNA Concentration in Midbrain Dopaminergic Neurons Is Differentially Regulated by Reserpine |
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| Authors: | Giulio M Pasinetti David G Morgan Steven A Johnson Sharon L Millar Caleb E Finch |
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| Institution: | Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191. |
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| Abstract: | Tyrosine hydroxylase (TH)-mRNA, assayed by in situ hybridization combined with TH immunocytochemistry, showed a selective increase in the ventral tegmental area (A-10) but not in the substantia nigra (A-9) midbrain dopaminergic (DAergic) neurons 3 days after reserpine treatment. TH-mRNA in locus ceruleus noradrenergic (A-4) neurons was increased by reserpine, as confirmed by RNA blot hybridization. These findings show that TH-mRNA is differentially regulated in midbrain DAergic neurons in response to reserpine. |
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| Keywords: | Tyrosine hydroxylase mRNA Reserpine Dopaminergic neurons In situ hybridization |
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