首页 | 本学科首页   官方微博 | 高级检索  
     


Ezetimibe blocks internalization of the NPC1L1/cholesterol complex
Authors:Chang Ta-Yuan  Chang Catherine
Affiliation:Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. ta.yuan.chang@dartmouth.edu
Abstract:Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex. The in vivo significance of these findings is discussed.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号