|
|||||
|
|
Novel benzimidazole derivatives as selective CB2 agonists |
|
| Authors: | Pagé Daniel Balaux Elise Boisvert Luc Liu Ziping Milburn Claire Tremblay Maxime Wei Zhongyong Woo Simon Luo Xuehong Cheng Yun-Xing Yang Hua Srivastava Sanjay Zhou Fei Brown William Tomaszewski Miroslaw Walpole Christopher Hodzic Leila St-Onge Stéphane Godbout Claude Salois Dominic Payza Kemal Payza Keymal |
| Affiliation: | Department of Medicinal Chemistry, AstraZeneca R&D Montréal, 7171 Frederick-Banting, St-Laurent, Que., Canada. daniel.page@astrazeneca.com |
| Abstract: | The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |