2′,3′-Dideoxy-3′-aminonucleoside 5′-triphosphates inhibit the repair of DNA in rat liver chromatin |
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| Authors: | A Krayevsky M Kukhanova L Alexandrova N Belyakova V Krutyakov |
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| Institution: | 1. Institute of Molecular Biology of the USSR Academy of Sciences, Vavilov str. 32, Moscow B-334, 117984, U.S.S.R.;2. B.P. Konstantinov Nuclear Physics Institute of the USSR Academy of Sciences, Gatchina, Leningrad District 188350 U.S.S.R. |
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| Abstract: | 2′,3′-Dideoxy-3′-aminonucleoside 5′-triphosphates are shown to be strong inhibitors of repair DNA synthesis in γ-irradiated rat liver chromatin. The activity of these compounds is comparable with that of the most effective inhibitor of the DNA polymerase β-catalyzed repair DNA synthesis. |
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| Keywords: | DNA repair DNA synthesis γ -irradiation Dideoxyaminonucleotide Nucleotide derivative (Rat liver) |
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