Hormonal regulation of benzo[a]pyrene metabolism in human adrenocortical cell cultures |
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| Authors: | P J Hornsby S E Harris K A Aldern |
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| Institution: | 1. Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China;2. Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;3. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China;1. Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;2. Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China;3. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China |
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| Abstract: | In cultured fetal human adrenocortical cells, metabolism of the carcinogen benzoa]pyrene was found to be unresponsive to the xenobiotic inducers 3-methylcholanthrene, benza]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, exposure of cultures to the hormone adrenocorticotropin (ACTH) for 48 hours stimulated benzoa]pyrene metabolism 3-fold. The major metabolite was the 7,8-diol. Other compounds which stimulate the production of adrenocortical cell cyclic AMP (forskolin and cholera toxin) as well as monobutyryl cyclic AMP also increased benzoa]pyrene metabolism. Human adrenocortical cells thus provide an unusual example of hormonal regulation of the metabolism of a carcinogen. |
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