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Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate |
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| Authors: | L. Giovagnini,L. Ronconi,L. Marchiò ,P. Brun,D. Fregona |
| Affiliation: | a Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy b Institute of Inorganic and Surfaces Chemistry, CNR Research Area, Corso Stati Uniti 4, 35127 Padova, Italy c Department of General and Inorganic Chemistry, Analytical Chemistry, Physical Chemistry, University of Parma, V.le G. P. Usberti 17/A, 43100 Parma, Italy d Department of Histology, Microbiology and Medical Biotechnology, Section of Microbiology and Virology, University of Padova, Via Gabelli 63, 35131 Padova, Italy e Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy |
| Abstract: | [RuCl3 · nH2O] and Na(trans-[RuCl4(DMSO)2]) were reacted with 1-pyrrolidinedithiocarbamate (PDT), its S-methyl ester (PDTM), and N,N-dimethylcarbamodithioic acid methyl ester (DMDTM) in water or methanol in order to obtain the corresponding Ru(III) derivatives. Once isolated and purified, the complexes were characterized by means of elemental analysis, conductivity measurements, FT-IR and 1H NMR spectroscopy, ion electrospray mass spectrometry (ESI-MS), and thermal analyses. The crystal structure of mer-[Ru(DMDTM)(DMSO)Cl3] has been also determined by X-ray crystallography. In vitro cytotoxic activity of all the synthesized complexes was eventually evaluated on some selected human tumor cell lines. |
| Keywords: | Ruthenium(III) complexes Dithiocarbamates Cytotoxic activity Anticancer drugs |
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