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Histidine analogues of oxytocin and vasopressin as efficient ligands for Zn ions - Potentiometric and NMR studies |
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| Authors: | Justyna Brasuń Marek Cebrat ?ukasz Jaremko Olimpa G?adysz |
| Institution: | a Department of Inorganic Chemistry, Wroc?aw Medical University, Szewska 38, 50-139 Wroc?aw, Poland b Faculty of Chemistry, University of Wroc?aw, F. Joliot- Curie 14, 50-383 Wroc?aw, Poland c Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland d College of Inter-Faculty Individual Studies In Mathematics and Natural Sciences, Warsaw University, ul. ?wirki i Wigury 93, 02-089 Warsaw, Poland e Slovenian NMR Center, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia |
| Abstract: | We have characterized the interaction between the Zn2+ ions and the histidine analogues of oxytocin and arginine-vasopressin. Potentiometric methods were used for the determination of the stoichiometry of the complexes formed and the calculation of their stability constants. The NMR measurements revealed detailed structures of the complexes and confirmed the binding mode at physiological pH. |
| Keywords: | Oxytocin Vasopressin Zinc ions Stability constants NMR structure Disulphide bridges Metal ion complexes |
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