|
|||||
|
|
Synthesis, characterization and crystal structure of novel mononuclear peroxotungsten(VI) complexes. Insulinomimetic activity of W(VI) and Nb(V) peroxo complexes |
|
| Authors: | Adamantia Maniatakou Mary Mavri Aris Terzis |
| Affiliation: | a Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou 15771, Greece b Biochemistry Laboratory, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou 15771, Greece c Institute of Materials Science, NCSR ‘Demokritos’, Aghia Paraskevi Attikis 15310, Greece |
| Abstract: | Two new mononuclear peroxo complexes of tungsten of the formula (gu)2[WO2(O2)2] (1) and (gu)[WO(O2)2(quin-2-c)] (2a) (where gu+ = guanidinium ion,  and quin-2-c = quinoline-2-carboxylate ion) have been synthesized and characterized by elemental analysis, infrared, Raman, UV-visible and 1H NMR spectroscopies. The crystal structure of (gu)[WO(O2)2(quin-2-c)] · H2O (2b) determined by X-ray diffraction indicates that the side-on peroxo groups and the bidentate quinaldate ligand bind the W(VI) centre leading to an hepta coordination mode. The guanidinium ion occurring as a counterion and the hydrogen-bound interactions stabilize the complexes. The in vitro insulin-mimetic effect of the complexes has been evaluated by the inhibitory effect on free fatty acid release in isolated fat adipocytes treated with epinephrine. Moreover the niobate analogues, synthesized and characterized previously, (gu)3[Nb(O2)4] and (gu)2[Nb(O2)3(quin-2-c)] · H2O have been tested for the insulin-like activity. |
| Keywords: | Tungsten Niobium Peroxo complexes Quinoline-2-carboxylate ligand X-ray structure Insulinomimetic activity |
| 本文献已被 ScienceDirect 等数据库收录！ | |