Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats |
| |
Authors: | Ming Li Wenjun Ding Debbie C Crans |
| |
Institution: | a College of Life Sciences, Graduate University of Chinese Academy of Sciences, No.19A YuQuan Road, Beijing 100049, China b Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA c Department of Chemistry, The University of Texas at Tyler, Tyler, TX 75799, USA |
| |
Abstract: | The evaluation of the anti-diabetic effects of an organic vanadium(V) complex in streptozotocin (STZ)-induced diabetic rats was investigated. The STZ-induced diabetic rats were orally administrated with sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate (V5dipic-NH2), a vanadium(V) coordination compound. The compound was administered through drinking water at a concentration of 0.1 mg/mL for 20 days, and then the concentration was increased to 0.3 mg/mL for the following 20 days. At the end of the experiment, V5dipic-NH2 statistically significantly reduced the levels of blood glucose (P < 0.01), serum total cholesterol (P < 0.01), triglycerides (P < 0.01) and the activities of serum aspartate amino transferase (P < 0.05) and alkaline phosphatase (P < 0.01) compared to untreated diabetic animals. After treatment with 0.3 mg/mL V5dipic-NH2, the oral glucose tolerance was improved in diabetic animals (P < 0.01). In addition, the daily intake of elemental vanadium was markedly decreased in V5dipic-NH2-treated diabetic rats compared to vanadyl sulfate (VOSO4)-treated diabetic rats, which suggested that the anti-diabetic activity of the element vanadium was elevated after being modified with an organic ligand. These results suggested that V5dipic-NH2, as an organic vanadium compound, is more effective than inorganic vanadium salt at alleviating the symptoms of diabetes. |
| |
Keywords: | Vanadium(V) Substituted dipicolinatooxovanadium(V) complex Anti-diabetic effects Streptozotocin-induced diabetic rats Blood glucose lowering Blood lipid lowering Structure activity relationships |
本文献已被 ScienceDirect 等数据库收录! |
|