| 石蒜碱抗炎作用研究进展 |
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| 引用本文： | 抗晶晶,王 辉.石蒜碱抗炎作用研究进展[J].中国野生植物资源,2013(6):1-3,13. |
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| 作者姓名： | 抗晶晶 王 辉 |
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| 作者单位： | 黄河科技学院医学院生化教研室,河南郑州450063 |
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| 摘 要： | 石蒜碱是从传统药用植物石蒜鳞茎中分离出的生物碱成分.已有研究表明石蒜碱具有良好的抗炎作月除对多种炎症模型都有明确的防治作用外,石蒜碱还可抑制LPS诱导的炎症相关诱导酶类的合成以及多种炎症质的释放.在石蒜碱抗炎的分子机制方面,石蒜碱可显著抑制脂多糖（LPS）诱导的P38和STATs通路的激活,而ERK1/2,JNK1/2和NF-κB通路无影响.
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| 关 键 词： | 石蒜碱 抗炎作用 炎症模型 炎症介质 信号转导 |
Progress in Researches for Lycorine in Anti-inflammatory |
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| Kang Jingjing,Wang Hui.Progress in Researches for Lycorine in Anti-inflammatory[J].Chinese Wild Plant Resources,2013(6):1-3,13. |
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| Authors: | Kang Jingjing Wang Hui |
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| Institution: | ( Department of Biochemistry, School of Medicine, Huanghe College of Science and Technology, Zheng- zhou 450063, China) |
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| Abstract: | Lycorine is a natural alkaloid extracted from the traditional medicinal plant Lycoris radiata bulbs. Existing research shows that lycorine has beneficial effect on anti-inflammatory. In addition to the prevention and treatment of several kinds of inflammation models, lycorine is also related to inhibiting the synthesis of enzymes and the release of inflammatory mediators induced by LPS. In molecular mechanism of anti-inflammatory, lycorine can significantly suppress the LPS-induced activation of P38 and STATs pathways but do not interfere with the phosphorylation of ERK1/2, JNK1/2 and NF-KB pathways. This article reviewed all the researches for lycorine in anti-inflammatory. |
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| Keywords: | Lycorine anti-inflammatory inflammation model inflammatory mediator signal transduction |
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