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Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1b |
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| Authors: | Annemarie Samalecos Katja Reimann Stefanie Wittmann Heinrich M Schulte Jan J Brosens Ana-Maria Bamberger and Birgit Gellersen |
| Institution: | (1) Endokrinologikum Hamburg, 20251 Hamburg, Germany;(2) Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, W12 ONN London, UK;(3) Section on Endocrinology and Ageing, University Clinic Hamburg-Eppendorf, 20251 Hamburg, Germany |
| Abstract: | BackgroundCoordinated differentiation of the endometrial compartments in the second half of the menstrual cycle is a prerequisite for the establishment of pregnancy. Endometrial stromal cells (ESC) decidualize under the influence of ovarian progesterone to accommodate implantation of the blastocyst and support establishment of the placenta. Studies into the mechanisms of decidualization are often hampered by the lack of primary ESC. Here we describe a novel immortalized human ESC line. |
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