Diagnosis of aspergillosis: Role of proteomics |
| |
Authors: | Leonardo Potenza Patrizia Barozzi Daniela Vallerini Eleonora Zanetti Giuseppe Torelli Mario Luppi |
| |
Institution: | (1) Department of General Internal Medicine, Gasthuisberg University Hospital, Leuven, Belgium |
| |
Abstract: | The expansion of the antifungal armamentarium and the implementation of imaging techniques and new nonculture-based fungal
diagnostics (NCBFDs) have improved the survival of patients with invasive asper-gillosis (IA). However, mortality rates still
remain high, possibly influenced by several pitfalls, affecting NCBFDs and reducing the window of opportunity for earlier
treatment. A large body of in vitro and in vivo studies has demonstrated that several fungal proteic components are strongly
immunogenic, and both the adaptive immunity and the innate branch are heavily involved in the recognition and clearance of
fungal pathogens, resulting, on occasion, in a useful tool for the treatment of IA. By evaluating these studies, this review
considers the possibility of exploiting either components of the innate or adaptive immunity to support the rapid and early
diagnosis of IA. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|