Immunocytochemical localization of secretory component in Paneth cell secretory granules-rat Paneth cells participate in acquired immunity |
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Authors: | Qing-Juan?Tang Email author" target="_blank">Kai-Zhong?TaoEmail author Yun-Liu Xue-Jun?Sun Mei-Yu?Geng Chun-Lei?Jiang |
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Institution: | (1) Department of Nautical Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China;(2) Department of Molecular Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao, P. R. China |
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Abstract: | Summary With the marker of Paneth cells-lysozyme, secretory component (SC) immunoreactivity was demonstrated exclusively in Paneth
cells of rat small intestine. The other types of epithelial cells (columnar, goblet, endocrine) were negative. On electron
microscopic level, many SC-positive colloidal gold particles were found in rough endoplasmic reticulum, Golgi complexes, basal
membrane and secretory granules of Paneth cells. These results suggest that SC is not a component of ingested immune complex,
but a membrane receptor on Paneth cell. It may function as receptor for polymeric IgA and mediate its transport across the
mucosal epithelium. Thus, Paneth cells are responsible for SC synthesis and participate in IgA-mediated acquired immunity
in rat small intestine. |
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