Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis |
| |
Authors: | Kawamoto S Kita M Hamada M Aki T Shigeta S Suzuki O Ono K |
| |
Institution: | Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, Japan. skawa@hiroshima-u.ac.jp |
| |
Abstract: | Although clinical evidence has suggested that dysregulated fatty acid metabolism is associated with atopic disorders, the molecular basis for such a correlation remains to be demonstrated. In the present study, we analyzed the fatty acid composition in peripheral blood cells of NC/Nga mice, a model for atopic dermatitis (AD). We found that arachidonic acid significantly accumulated in mice with the AD manifestation. In addition, the leucotriene B4-releasing ability upon calcium ionophore A23187 stimulation was potentiated in blood cells. An arachidonic acid accumulation was not apparent in the non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice fed under specific pathogen-free conditions. These results indicate that a disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for their dermatitis development. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|