| Affiliation: | (1) Department of Ecology and Genetics, University of Aarhus, Aarhus C, Denmark;(2) Bioinformatics Research Center (BiRC), University of Aarhus, Aarhus C, Denmark;(3) Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, Tjele, Denmark;(4) Department of Animal Science and Animal Health, KVL, Frederiksberg C, Denmark |
| Abstract: | Background The availability of abundant sequence data from key model organisms has made large scale studies of molecular evolution an exciting possibility. Here we use full length cDNA alignments comprising more than 700,000 nucleotides from human, mouse, pig and the Japanese pufferfish Fugu rubrices in order to investigate 1) the relationships between three major lineages of mammals: rodents, artiodactyls and primates, and 2) the rate of evolution and the occurrence of positive Darwinian selection using codon based models of sequence evolution. |
