Immune response to the H-X antigen on P815-X2 |
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Authors: | Larry W Kwak Roger W Melvold R Michael Williams |
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Institution: | (1) Section of Medical Oncology, Departments of Medicine and Microbiology-Immunology and the Cancer Center, Northwestern University Medical School, 60611 Chicago, Illinois |
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Abstract: | In a preceding report, the detection of an H-2-linked immune response to the H-X
d
antigen on the P815-X2 mastocytoma was demonstrated by the significantly increased survival of (C57BL/6 × DBA/2)F1 (B6D2F1) male hybrids (H-X
b
) compared with female siblings (H-X
b/H-X
d
) after injection with the histocompatible tumor (H-X
d
). This interpretation was supported by the absence of this sex effect in reciprocal D2B6F1 hybrids (H-X
d
and H-X
d/H-X
b
). Additional findings presented in this paper support the conclusion that this sex effect is due to a true immunological response to H-X
d
: (a) Reciprocal (DBA/2 × C57BL/6 H-2 mutant)F1 hybrids, as well as D2B6F1, failed to exhibit the sex effect: (b) the demonstration of the sex effect in (BALB/c × DBA/2)F1 and (BALB/c-H-2
dm2
× DBA/2)F1 hybrids and in (C57BL/10 × DBA/2)F1 hybrids was consistent with the known H-X incompatibilities between the strains BALB/c and DBA/2 and C57BL/10 and DBA/2, respectively, previously demonstrated by skin grafting; and (c) the sex effect was not abrogated by castration of male B6D2F1 hybrids. Variability in the presence or absence of the sex effect was observed in various recombinant inbred (RI) × DBA/2]F1 hybrids and may be attributed to the influence of a regulatory non-H-2 gene which is closely linked to the gene coding for mouse kidney-androgen-regulated protein (KAP) but androgen-independent, or to variability in inheritance of the H-X
b
allele among the RI lines. It is proposed that the P815-X2 model may be utilized to type RI lines derived from a cross between C57BL/6 and DBA/2 for their H-X genotypes.Abbreviations B
C57BL/6 origin allele
- B6
C57BL/6
- B10
C57BL/10
- B6D2F1
(C57BL/6 × DBA/2)F1
- B6
m
D2F1
(C57BL/6 H-2 mutant × DBA/2)F1
-
bm10
B6.C-H-2
bm10
- C
BALB/c
- D
DBA/2 origin allele
- D2
DBA/2
-
dm2
BALB/c-H-2
dm2
- H-X
X chromosome-determined histocompatibility antigen of the mouse
-
Ir
gene, immune response gene
- KAP
kidney androgenregulated protein
- MST
median survival time
- RI
recombinant inbred
- SDP
strain distribution pattern |
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Keywords: | |
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