The contested role of uracil DNA glycosylase in immunoglobulin gene diversification |
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Authors: | Longerich Simonne Storb Ursula |
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Affiliation: | Department of Molecular Genetics and Cell Biology, Committee on Immunology, University of Chicago, IL 60637, USA. |
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Abstract: | Class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes are initiated by the activation-induced cytosine deaminase AID. The resulting uracils in Ig genes were believed to be removed by the uracil glycosylase (UNG) and the resulting abasic sites treated in an error-prone fashion, creating breaks in the Ig switch regions and mutations in the variable regions. A recent report suggests that UNG does not act as a glycosylase in CSR and SHM but rather has unknown activity subsequent to DNA breaks that were created by other mechanisms. |
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