Modulation of host defense by the neuropeptide alpha-MSH |
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| Authors: | J M Lipton |
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| Institution: | Department of Physiology, University of Texas Southwestern Medical Center, Dallas. |
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| Abstract: | alpha-melanocyte stimulating hormone (alpha-MSH), a peptide that occurs within the brain, the circulation, and other body sites, is a potent antipyretic agent when given centrally or peripherally. The peptide likewise inhibits inflammation and aspects of the acute-phase response. The combined evidence suggests that alpha-MSH molecules act as natural modulators of host reactions by antagonizing the central and peripheral actions of cytokines. |
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